Archive for Scientific Discovery

West Hartford Science Walking Tour: Golf Acres/Aiken District

Start at 333 North Steele Road

Photo of Suzanne Corkin

Suzanne Corkin

Suzanne Corkin (née Hammond) was born at Hartford Hospital and was an only child. Dr. Corkin grew up in West Hartford, directly across the street from William Scoville, at 333 North Steele Rd, and was best friends with his daughter, Alison Scoville Dittrich. The two went to school together from third grade until college and stayed very close after that. Dr. Corkin went to the Oxford School in West Hartford. She went to college at Smith College and then received her PhD from McGill University. While there, she read an article about Henry Molaison.  Mr. Molaison received psychosurgery at Hartford Hospital to relieve seizures and was left with a profound memory deficit.  You can learn more about him and the surgery here.  Her dissertation advisor, Brenda Milner, asked if she would like to work with him. Her dissertation was entitled “Somesthetic function after focal cerebral damage” which examined Mr. Molaison’s sense of touch. In 1964 she began working at the Massachusetts Institute of Technology in the lab of Hans-Lukas Teuber. When he died, she became the director of the lab. She devoted her career to working with Mr. Molaison and to studying how human memory works and the brain substrates of memory in a variety of populations.  She discovered that Mr. Molaison had profound short-term memory loss.  He could remember very little from after the time of the surgery for the rest of his life.  According to Dr. Corkin: If you talked to him in the afternoon and said, “Have you had lunch?,” he would say, “I don’t know” or “I guess so,” but he would not remember what he had had. And if you asked, “What was your last meal?,” he wouldn’t know what it was.

She was an early user of functional imaging like MRI and fMRI to help understand how memory works. She published over 150 research articles and was author or co-author of 10 books. She received a MERIT award from the National Institutes of Health and the Baltes Distinguished Research Achievement Award from the American Psychological Association, Division on Aging. She also became a committed advocate for increasing women in science, giving talks on the topic, and received the Brain and Cognitive Sciences Undergraduate Advising Award at MIT. After her death, a group of former students published this tribute to her.

We were fortunate to have Dr. Corkin speak at Trinity College. You can watch the full talk here “The Amnesic Patient HM: A Half Century of Learning About Memory.”

Here is a clip where she talks about whether Mr. Molaison has a sense of self.

Short-Corkin-Clip

Suzanne Corkin Obituary

After her death, Dr. Scoville’s grandson, Luke Dittrich wrote a book Patient H.M.: A Story of Memory, Madness, and Family Secrets. In it he claimed that Dr. Corkin tried to hide the existence of a lesion in the orbitofrontal lobe and that she shredded data to cover errors. This was refuted in a letter to the New York Times signed by over 200 scientists, and in the published work. In fact, she had published data that she claimed suggested an orbitofrontal lesion in 1983 (Eichenbaum et al., 1983).

In Defense of Suzanne Corkin

 

Directly across the street at 334 North Steele Road was the home of William Beecher Scoville, the surgeon who performed the surgery on Mr. Molaison.

photo of Dr. Scoville

William Beecher Scoville

William Beecher Scoville established the Department of Neurosurgery at Hartford Hospital in 1939. William Beecher Scoville was a descendent of Harriet Beecher Stowe. He was born in Philadelphia in 1905 to Samuel and Katherine Gallaudet (Trumbull) Scoville. His mother was a descendant of Thomas Gallaudet. He attended Loomis School, received his undergraduate degree at Yale University and his medical degree at the University of Pennsylvania. His first wife was Emily Learned Scoville and they had three children that they raised at 334 North Steele Road in West Hartford, Barrett, Alison, and Peter. In 1941 he developed the first neurosurgery residency program in Connecticut. His students referred to him as “Wild Bill.” ‘Bill drove fast, lived hard and operated where angels feared to tread,” said Dr. David Crombie, former chief of surgery at Hartford Hospital who met Scoville in the early 1960s as an intern at the hospital and became friends with his son. Scoville’s wife had schizophrenia and this may have played a role in his desire to find surgical options for treating mental illnesses. In the book written by his grandson, Luke Dittrick, Dittrick speculates that Dr. Scoville may have actually performed surgery on his wife, Emily Learned Scoville.

photo of aneurysm clip

Scoville’s aneurysm clip

In addition to the surgery on Mr. Molaison, Dr. Scoville is known for a coiled aneurysm clip that he invented. His second marriage was to Helene Deniau Scoville, with whom he had two children Sophie and William. Dr. Scoville’s brother was Rev. Gordon Scoville, the founding pastor of Westminster Presbyterian Church in West Hartford. Dr. Scoville had a life-long interest in cars and was known for driving his red Jaguar or motorcycle on Steele Road and tinkering with cars in his spare time. He was an early proponent for motorcycle helmets but never wore one himself. Scoville was killed in 1984, at the age of 78, when he backed up his car on the highway to get to an exit he had missed.

 

 

West Hartford Science Walking Tour: Farmington East/Whiting Lane District

 

Start at 193 Arnoldale Road

photo of women physicians

Fanny Radom is second from left in this photo

Dr. Fanny Radom (second from left in photo) was born in the Ukraine on December 28, 1878. She came to Hartford in 1893. At the time there were only about 2500 Jews in Hartford. She graduated from the Brooklyn College of Pharmacy and the Women’s Medical College of Pennsylvania. She was one of the first licensed women pharmacists in the state of Connecticut. This is especially impressive given that there were unspoken quotas to exclude Jews to medical schools and residencies and there were only 28 Jewish physicians in Hartford overall. Despite being one of the few women doctors at the time, she was one of the founding physicians of Mount Sinai Hospital in 1923. At the time Jewish doctors were not permitted hospital privileges at Hartford Hospital or Saint Francis Hospital. Most were forced to practice in smaller community hospitals outside the city even though most of their patients lived in the city. There was no place where Jewish patients felt welcome and Jewish physicians could practice a full range of specialities. Dr. Radom first lived and practiced at 336 Windsor Ave in Hartford. She then had a practice at 2094 Main Street in Hartford and lived at 193 Arnoldale Road in West Hartford. She died September 12, 1948 and is buried at Zion Hill Cemetery.

The Practice of Medicine and Prejudice in a New England Town: The Founding of Mount Sinai Hospital, Hartford, Connecticut

Dr. Fanny Karp Radom

 

 

Walk north on Arnoldale Road until you cross Farmington Avenue. Enter the West Hill Drive loop.

56 West Hill Drive was the home of Edward Lorenz

photo of Edward Lorenz

Edward Lorenz

Edward Norton Lorenz: The Butterfly Effect
Almost everyone is familiar with some notion of the “the butterfly effect”, but few outside the scientific community know the name Edward Norton Lorenz (May 23, 1917 – April 16, 2008), born in West Hartford, Connecticut. Edward Lorenz was an American meteorologist and mathematician who was the first to recognize chaotic behavior in the mathematical modeling of weather systems which sparked a scientific revolution called chaos theory. This became known as the “butterfly effect” after a 1972 talk at the annual meeting of the AAAS given by Lorenz that was titled “Does the flap of a butterfly’s wings in Brazil set off a tornado in Texas.”

A simplified explanation of “the butterfly effect” is that small initial conditions, even far away, can have significant impact on large events through non-linear dynamics. We know very little about Ed Lorenz’ early childhood at 56 West Hill Drive, West Hartford, Connecticut, but we do know it was here that he first became interested in mathematics, chess and astronomy, and … weather. Perhaps these “initial conditions” ultimately resulted in his discovery of a fundamental “chaos theory” underlying much of modern science. This marked the beginning of a new field of study that impacted the fields of virtually every branch of science: mathematics, biology, physics, sociology, etc.

“…the advent of chaos theory in the second half of the twentieth century has brought about a revolution in science; hardly any scientific discipline (whether on the physical or biological side) has been untouched by it. In its essence, this revolution has been brought about by a paradigm shift to rival that of quantum theory, or relativity theory.”

While his discoveries impacted science more broadly, much of Lorenz research centered around weather. After helping the US Army Air Corp pilots forecast weather in the Pacific during WWII, he continued applying mathematics to his pioneering work on weather and climate theory. The ensemble forecast methodologies he created are now being utilized in predicting climate change.

In honor of 100th birthdayl

Biography of Lorenz

 

 

Continue east on Farmington Ave to Highland Street and turn right to 17 South Highland. This was the home of Nobel Prize Winner John Enders.

photo of John Enders at a microscope

John Enders

John Enders was born in West Hartford, CT in 1897. He went to the Noah Webster School at Hartford and St. Paul’s School in New Hampshire. He attended Yale University for one year and left to pursue a career as a pilot in the Air Force in 1918. After fighting in World War I, he returned to Yale to finish out his degree. He then went on to study English, German, and Celtic Literature. To finish out his education, he earned his Ph.D. in bacteriology and immunology.

In 1946, after years of research Enders established an infectious disease lab at the Children’s Medical Center in Boston, MA. In 1954, Enders was awarded the Nobel Prize in Physiology or Medicine. He had successfully cultivated the poliomyelitis virus in non-nervous tissue. Enders and his colleagues found changes in cell tissue under a high-powered light microscope. They were able to detect the poliovirus growing which became the new way to confirm the presence of the virus.

In 1961 he was named one of Time magazine’s Men of the Year

He has been called the father of modern vaccines

Nobel prize information

John Enders biography

 

 

 

 

Published in: Scientific Discovery, Walking Tours, West Hartford on May 13, 2024 at12:01 am Comments (0)